Well considering I'm on top about 85-90% of the time on my team when I play, I can honestly say NO it doesn't hinder my play.
Secondly you obviously didn't read my post closely, there are default keys in game that are set period. All the things you posted, if you read my post, would know, are NOT needed. BOLT ONLY!!!
NO MELEE - no need for bayo
And with everything I use is more than enough help for the team and for my gameplay (So you obviously NEVER played with or against the CLOWN)
So everything you just posted is NOT needed except maybe a lean here or there which are default keys at Q and W.
I just don't use them all and I don't need them to play normally, but the poster stated 25 keys, holy cow what game is that for and to bind to a controller, it's been done over and over again in FPS on consoles (NOTHING NEW).
I have a 5 button mouse and like 6 keys on the keyboard needed for me to play normally.
I don't drop weapons, and the USE key which is on my mouse is for resupply as well as doing most of the stuff you mentioned.
I do use voice, 3 keys period, I-O-P, I=team, O= hold to speak, P=public.
You also must be new to the game to not know about my style and gameplay and the wrath the CLOWN brings???
I'm on almost every night on TWB "Old Glory" East Coast 50 Player feel free to come and see the CLOWN in action and believe me you'll HEAR ME rallying the troops and on VOICE 99% of the time and yes using one finger my thumb on my 5 button mouse and the use of 6 keys on the keyboard...