Whats your OS and ram? Random crashes like that are caused by setting textures to too high a setting, and/or having something else taking up too much memory, like antivirus or antimalware.
Win7, 8 GB RAM, AMD Athlon II X2 215 processor, Geforce 8800 GTS 512 MB gfx card.
I am currently running the second lowest resolution, and except for the settings on your ini, everything on medium, with bloom turned off.