Bedlam: A couple of friends and i have been having some trouble on it but i think we figured out something that works. Im not sure how this works with lower lvl perks but...Me and 3 friends are all lvl 6 sharpshooters. So we find a stairway (there is two but try and find the one near 2 traders that is more lit up then the other one) and have 2 people covering the top and 2 people covering the bottom. 1 person have an m14 and the other has an xbow for easy scrake/fp headshots. Each two man team drops pipes on the other people so if they get overwhelmed, pipes blow up. This seemed to work well for me.
Wyre: I like to use the tunnels underground. You can use the first room next to the stalkers with darts in em, and weld the door. You can shoot through the fence but make sure you have a support continuosly welding. Have 2-3 watching that way and everyone else watching straight ahead. You can also find the hallway directly to the left of that and just have 3 people watching one way and 3 watching the other. having 1 sharp, 1 support, and 1 commando watching each way is preferable. This tactic also worked for me. This worked better for me than the other one above.
hope this helps some!