Do you mean sitting in the doorway, blocking it and stopping zeds from coming through?
It's a great strategy on earlier difficulties, but I've never made it work on later ones (particualrly HoE) because the zerker will get his armour eaten early on (duh). But when a scrake comes, or a FP if he rages early, he will kill the berserker in two hits on 100 HPs with no armour. Yes, if the zerker is good or sees the scrake coming, he can swap to an axe, and hopefully land a stun on his head before getting hit a second time, or the fleshpound will (hopefully) get killed before it can rage a second time. But unless you can stun EVERY scrake and kill EVERY fleshpound before being hit twice (and assuming the medic has enough time to heal you before the next one arrives). With 4 players (which I'm assuming you'll have. More than that and the zeds will be strong enough to make things harder, and much less and you won't have enough killing power on big nasties) you'll have twin scrakes spawning, if not twin fleshpounds.
It's a possible strategy. IMHO, it's far from an ideal strategy. I'd much rather everyone stay back a bit and just shoot, with a medic able to jump in front of a scrake of FP if needed. It's worked for me in that exact spot on Aperture without a hitch.