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Once you're level 25 and have Nuke, buy the C4 on wave 2 or 3.

Whatever area you're camping, generally most Zed's will be coming from one area. For example, when camping Artic Cats on Outpost, most of the enemies will be coming from the locker room at door 4.

Throw a C4 into the room, and the run over to the other main area Zed's come from, with the exit from the building, under a balcony, under the heli-pad where Zed's spawn.

Stay there and blast away with your M79/HX25.
While you are shooting there, a Zed Time will occur during the wave.
If you have your M79 pointed at a bunch of Zeds, ignore the C4 and blast away!
But, if there are no enemies in front of you, or you are in the middle of reloading, when Zed Time occurs, quickly switch to C4, and tap secondary fire as fast as you can.
Chances are, since that is a Zed heavy entry point, you'll get a bunch of kills, not only from the blast, but from the radiation.
Go back, place your C4, then run back ti the other spot.
It may also happen, that when a Zed Time occurs, you ignore your C4 and choose to blast a group of Zeds or a SC/FP, but a Commando popping heads gives an extension and you can switch to C4, interupting your weapon reload, quckly repeatedly taping secondary fire to make sure the C4 explodes during Zed time, and you get TWO Nuke explosions during one Zed time.

It goes without saying you'll want to use all your C4 each wave, because the cheapest way to buy C4 is to sell the detonator for 487(i think) and rebuy it for 650, getting 8 C4 for $162 instead of the ludicrous price of $800

Also, for Hans, when he's chasing a team mate or grabbed one during his heal phase, is a really good time to stick him with as many C4 as you can. Often right after from killing the Zeds that will appear during his heal phase, Zed Time will occur, and you can blast the C4 stuck to him for the radiation damage. Multiple Nuke damage stacks, so blast away!
Doing this, you can Nuke him every time Zed Time occurs, which is especially useful after his final heal phase when he seems most likely to trigger Zed Time by killing a player.

So give it a shot and say what you think!

Edit: corrected info on radiation damage stacking