You just activated my nerdgasm my friend ! I'm absolutely obsessed with Cronenberg's early cinematography. And biological weaponry is always something I love : either from the Zergs and Tyranids (from Starcraft & Warhammer respectively), from Half-Life, and so on...
Sadly, coming from Tripwire, I suppose it would end up as skins rather than new weapons...And it doesn't help that no zeds actually uses bioweapons either (the husk uses a real cannon, the scrake uses a real chainsaw etc.)
But I would love to have something akin to the gore shiv. I'm sure Horzine wouldn't be against weaponizing flesh... It's pretty much what the whole ZED project is anyway