I didn't rigorously compare with using Radeon Pro, but I prefer using these profiles than RP now.
Raw performance is maybe a little worse than using RP and forcing a profile, but effects like suppression, smoke and blur are a little more attractive and your frames actually increase when you turn options like ambient occlusion off, rather than increasing when you turn them on: i.e. it scales better.
I'm getting more hitching and areas of the map where my frame rates stutter now, though. Card temperatures are higher than before, so it's definitely spreading the load between processors. Didn't bother to double check with GPUZ, since it was obviously working.
HD4870x2 + 4870.