FYI I run the game at 1280x1024 res on a 19" Sony monitor. I suffer from farsightedness (hyperopia) and have an astigmatism in my right eye, and am blind in my left. To see anything CLOSER than about 400 yards clearly I require optical correction. That means I wear bifocals or reading glasses from the time I get up until the time I get to sleep. I wear my reading glasses when on the computer, which means I have to sit where my eyes are exactly 17" from the monitor to see without eyestrain.
I have no problems at all using the iron sights on ANY weapon on the game, at any range available in the game.
I have HDR bloom turned off, as well as coronas, to help get everything as sharp as possible in-game. Yes, the front sight blade is sometimes hard to see, but guess what, that's the way it can be in real life as well. Thousands of hours spent looking over iron sights in over 30 years of sporting and competitive shooting have taught me that your front sight WILL disappear, most particularly when the target's background is similar in color to your sight blade. ESPECIALLY when the sight blade in question has suffered wear in a combat environment, as witnessed by the surplus military rifles I have fired that had sight blades ranging from darkly phosphated/blued to nearly mirror bright from being rubbed against various surfaces.
However, it isn't just screen resolution, it's also the size of the pixels on your screen. My monitor (Dell labeled Sony 19") has a .27mm dot pitch (pixel width). That's actually a bit on the large size (.22mm DP is the smallest I'm aware of) but allows me to run the higher resolutions with absolute clarity, even with my bad eyesight. A simple rule of thumb is the larger the dot pitch, but fuzzier the image appears. LCD screens can be even worse due to ghosting and extreme pixellation on some lower-quality monitors.
My honest opinion? Leave the game as-is.